1.ΔE≠E: important to make processes occur. As r decreases, the surface area & quantum mechanics become important

2.Intermolecular forces

3.Scale: instrumentation

4.Ratio

5.Life as natural nanotech (we use it as a template)

6.Faith in “nano” science and empirical evidence

7.What makes a nanoscale system unique?

8.Given many forces, identify (dominant <-> regime correlation)

9.Necessity for tunable depth

10.Realm of validity of each model